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Effect of NF-ΚB inhibitors in rSARS-CoV-MA15-infected mice. Sixteenweek-old mice were intranasally infected with 100,000 PFU of rSARS-CoV-MA15 or mock infected. At 4 hpi and every 24 h from days 1 to 4, mock-infected and wild-type (wt)-infected mice were intraperitoneally injected with CAPE (wt,+C), parthenolide (wt,+P), both CAPE and parthenolide (wt,+C +P), or vehicle (wt,-).

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炎症浸润,肺水肿